A while back I wrote a post regarding our lack of complete knowledge and how, rather than being a bad thing, it is actually a good thing. I've also written regarding the fact that our knowledge will never be complete, which is something that we must get used to and be comfortable with.
This is true regardless of which worldview that one holds. However, many people act as if they require complete knowledge and understanding of a worldview before they decide to accept it as true. They argue that since they do not want to blindly accept a worldview that may be false, they must not accept a worldview unless they have certainty that it does not contain any falsehoods. On the surface, this is being quite careful. But we must remember that while we are investigating one worldview, we are holding another- that we are not investigating (maybe we haven't ever, maybe we have in the past). I have heard it commonly put that "the skeptic must be skeptical of his skepticism" to avoid being dishonest. Even skepticism must be investigated and justified, though.